What is the route of administration for Aqueous Crystalline Penicillin G in Neurosyphilis treatment?

The primary route of administration for Aqueous Crystalline Penicillin G in the treatment of neurosyphilis is intravenously for 10-14 days. This method is essential because neurosyphilis involves the central nervous system, and adequate drug levels need to be achieved rapidly to effectively penetrate the blood-brain barrier. Intravenous administration ensures that high concentrations of the antibiotic can be delivered directly into the bloodstream, allowing for immediate systemic effects.

Oral administration is not suitable for treating neurosyphilis because the levels of penicillin that would be achieved in the bloodstream may not be sufficient to treat the infection effectively. Intramuscular administration is also less ideal for neurosyphilis, as it may not provide the sustained high levels of the drug that are necessary for penetrating the central nervous system tissues. Topical treatment is inappropriate for this condition since neurosyphilis is a systemic infection that requires a more aggressive and targeted approach.

Thus, the intravenous route for a minimum of 10-14 days is the standard protocol to ensure the successful treatment of neurosyphilis with Aqueous Crystalline Penicillin G.