What is the recommended first-line treatment for Streptococcal Pharyngitis?

The recommended first-line treatment for Streptococcal Pharyngitis is Amoxicillin. This antibiotic is favored primarily due to its effectiveness against the leading causative bacteria, Group A Streptococcus (Streptococcus pyogenes). Amoxicillin, which is a penicillin-type antibiotic, works by inhibiting bacterial cell wall synthesis, leading to cell death and clearing the infection.

Amoxicillin is preferred for several reasons: it is well-tolerated by patients, has a favorable dosing schedule, and is effective in treating the infection without significant resistance issues when used appropriately. Additionally, it has the advantage of being available in various formulations, including liquid for children who may have difficulty swallowing pills.

In contrast, other choices like Ceftriaxone are typically reserved for more severe infections or those requiring parenteral administration rather than oral therapy. Doxycycline, while effective against various bacterial infections, is generally not the first-line treatment for Streptococcal Pharyngitis, especially in children due to concerns about staining of teeth and its association with increased susceptibility to resistant strains. Clindamycin, on the other hand, is sometimes used for penicillin-allergic patients or in cases of recurrent infections, but it is not the