What is the recommended first-line medication for tinea corporis?

The recommended first-line medication for tinea corporis is terbinafine. This antifungal is effective against dermatophytes, which are the primary pathogens causing tinea infections such as tinea corporis. Terbinafine works by inhibiting the enzyme squalene epoxidase, leading to a decrease in ergosterol synthesis, an essential component of fungal cell membranes. This action ultimately disrupts cell membrane integrity and leads to cell death, providing a strong therapeutic effect against the fungal infection.

While griseofulvin is also an antifungal medication that is used for dermatophyte infections, it is typically reserved for cases where other treatments have failed or for specific indications like tinea capitis. Clotrimazole and ketoconazole are effective antifungals as well, but they are often used for superficial infections or topical treatments. Terbinafine’s systemic availability and potency make it the preferred choice for treating tinea corporis.