What is the first-line treatment for arthritis associated with Rheumatic Fever?

The first-line treatment for arthritis associated with Rheumatic Fever is high-dose NSAIDs. This approach is used to manage the inflammation and pain caused by arthritis in the context of rheumatic fever, which is a complication following streptococcal throat infection. High-dose nonsteroidal anti-inflammatory drugs (NSAIDs) help alleviate the joint symptoms effectively and are generally well-tolerated.

Corticosteroids, while they can be used in severe cases of rheumatic fever, are not typically the first-line treatment for arthritis unless the NSAIDs are ineffective or there is a more severe inflammatory response. Oral Penicillin is essential for preventing further infections and treating the underlying streptococcal infection but does not directly address the arthritis symptoms. IV Clindamycin is used for certain severe soft tissue infections or when there is an allergy to penicillin, but it is not relevant to the treatment of arthritis associated with rheumatic fever. Therefore, high-dose NSAIDs are the most appropriate initial therapy for managing arthritis in this context.