What is the first-line treatment for an uncomplicated skin and soft tissue infection caused by Streptococcus or Staphylococcus?

Cephalexin is the first-line treatment for uncomplicated skin and soft tissue infections caused by Streptococcus or Staphylococcus species due to its efficacy against these common pathogens. It is a first-generation cephalosporin antibiotic that effectively targets gram-positive cocci, making it ideal for handling infections like cellulitis and minor skin abscesses, which are often attributed to these bacteria.

Cephalexin is typically well-tolerated and has a favorable pharmacokinetic profile, allowing for good tissue penetration and appropriate dosing intervals. This makes it an excellent choice for outpatient treatment of mild infections where the causative organisms are likely to be susceptible.

While other antibiotics listed have their indications, such as clindamycin for patients with penicillin allergies or in cases of suspected necrotizing infections, cephalexin remains the preferred option for straightforward cases involving the mentioned pathogens.